Date of Award
1-1-2010
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (xii, 74 pages) : illustrations (some color)
Dissertation/Thesis Chair
Igor K Lednev
Committee Members
George I Makhatadze, Rabi A Musah, Jayanti Pande, Alexander Shekthman
Keywords
aggregate, amyloid, fibril, protein, Raman, spectroscopy, Raman spectroscopy, Proteins, Amyloid beta-protein
Subject Categories
Analytical Chemistry | Biochemistry | Physical Chemistry
Abstract
The structures and properties of amyloid fibrils are of considerable interest due to their associations with numerous neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and transmissible spongiform encephalopaties (prion diseases). Understanding fibrillogenesis at a molecular level requires detailed structural characterization of amyloid fibrils. However amyloid fibrils are difficult objects to study due to their non-crystalline and insoluble nature. These properties make the application of classical tools of structural biology, such as X-Ray crystallography and solution Nuclear Magnetic Resonance spectroscopy, impractical for structural characterization of protein fibrils.
Recommended Citation
Popova, Ludmila A., "Elucidating the structure of protein aggregates by Raman spectroscopy" (2010). Legacy Theses & Dissertations (2009 - 2024). 238.
https://scholarsarchive.library.albany.edu/legacy-etd/238