Date of Award
1-1-2017
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biomedical Sciences
Content Description
1 online resource (xiv, 359 pages) : illustrations (some color)
Dissertation/Thesis Chair
Kathleen A McDonough
Committee Members
Harry W Taber, Nicholas J Mantis, Joseph T Wade, Karsten R.O Hazlett
Keywords
Cmr, CRP family, DosR, transcription factor, Mycobacterium tuberculosis, Genetic transcription, Genetic regulation
Subject Categories
Biochemistry | Microbiology | Molecular Biology
Abstract
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans, is an intracellular pathogen that infects millions of people every year. Mtb can survive inside the host for extended periods of time by sensing and adapting to the host environmental stressors. Transcriptional gene regulation plays a critical role in this adaptation. This dissertation focuses on understanding the structural and functional aspects of one such transcriptional regulatory unit, Cmr (Rv1675c), in Mtb.
Recommended Citation
Ranganathan, Sridevi, "Structural and functional characterization of an unusual cAMP responsive transcription factor, Cmr, in Tb complex mycobacteria" (2017). Legacy Theses & Dissertations (2009 - 2024). 1923.
https://scholarsarchive.library.albany.edu/legacy-etd/1923