Date of Award
1-1-2014
Language
English
Document Type
Master's Thesis
Degree Name
Master of Science (MS)
College/School/Department
Department of Chemistry
Content Description
1 online resource (viii, 45 pages) : color illustrations.
Dissertation/Thesis Chair
Jayanti Pande
Committee Members
Alexander Shekhtman
Keywords
Biophysical Chemisty, Crystallin, Deamidation, Disulfide, Lens Proteins, Post Translation Modifications (PTMs), Cataract, Crystalline lens
Subject Categories
Biochemistry | Chemistry | Physical Chemistry
Abstract
Cataract is the leading cause of blindness in the world. Cataractous lenses scatter a significant part of the light entering the eye. Cataract can be of several types: Age-related cataract, secondary cataract, traumatic cataract, congenital cataract, and radiation cataract. Age-related cataract is the most common type of cataract. Several factors contribute to age-onset cataract; among them are the Post-Translational Modifications (PTMs) to the major lens proteins or crystallins, which constitute about 80-90% of the protein content of the lens. Predominant PTMs of the crystallins are oxidation, deamidation, phosphorylation, glycation, and disulfide crosslinking, which tend to increase as the lens ages.
Recommended Citation
Salami, Christiana Oluwaseun, "Modeling the early, aging-related changes in human recombinant gammas-crystallin in vitro" (2014). Legacy Theses & Dissertations (2009 - 2024). 1260.
https://scholarsarchive.library.albany.edu/legacy-etd/1260