Date of Award
1-1-2014
Language
English
Document Type
Master's Thesis
Degree Name
Master of Science (MS)
College/School/Department
Department of Chemistry
Content Description
1 online resource (iv, 89 pages) : color illustrations.
Dissertation/Thesis Chair
Daniele Fabris
Keywords
Ion mobility spectrometry-mass spectrometry, Nucleic Acids, Nucleic acids, Ion mobility spectroscopy, Mass spectrometry, DNA-ligand interactions, Ligand binding (Biochemistry)
Subject Categories
Analytical Chemistry | Biochemistry | Chemistry
Abstract
Three-dimensional structures of biopolymers frequently dictate the biological role those molecules play. As such, investigation into structure of nucleic acids can provide important information pertaining to how those nucleic acids work. Many nucleic acid species, especially single-stranded RNA, fold into unique structures that allow them to function properly. Metals, and other cationic species, are often bound to the nucleic acid to make folding into the proper structure more favorable by neutralizing the negative charge on the nucleic acid imparted by the phosphate group. This investigation explores tertiary structure of nucleic acids that have been folded in the presence of ligands using ion mobility spectrometry-mass spectrometry (IMS-MS).
Recommended Citation
Redick, Bill Kenneth, "Monitoring ligand-induced nucleic acid conformational changes using ion mobility spectrometry-mass spectrometry" (2014). Legacy Theses & Dissertations (2009 - 2024). 1246.
https://scholarsarchive.library.albany.edu/legacy-etd/1246