Date of Award

1-1-2013

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Environmental Health Sciences

Content Description

1 online resource (xii, 157 pages) : illustrations (some color)

Dissertation/Thesis Chair

Qing-Yu Zhang

Committee Members

Xinxin Ding, Robert Turesky, Laurence Kaminsky, Erasmus Schneider, David C Spink

Keywords

Cytochrome P450, Intestine, Intestine, Small, Cytochrome P-450, Xenobiotics, Mice as laboratory animals

Subject Categories

Pharmacology | Public Health | Toxicology

Abstract

The overall goal of this thesis work was to investigate the function and regulation of intestinal P450 enzymes (P450s). The central hypotheses are that 1) small intestinal (SI) P450s play an important role in the first-pass clearance of oral drugs and in bioactivation of chemicals that cause intestinal toxicity, 2) endogenous regulatory compounds produced by intestinal P450s are important for protection against chemical-induced colon inflammation, and 3) there is a cross talk between the liver and the SI that helps to maintain the overall xenobiotic-metabolism capacity of the digestive tract.

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