Document Type


Publication Date




Core/shell nanofibers are becoming increasingly popular for applications in tissue engineering. Nanofibers alone provide surface topography and increased surface area that promote cellular attachment; however, core/shell nanofibers provide the versatility of incorporating two materials with different properties into one. Such synthetic materials can provide the mechanical and degradation properties required to make a construct that mimics in vivo tissue. Many variations of these fibers can be produced. The challenge lies in the ability to characterize and quantify these nanofibers post fabrication. We developed a non-invasive method for the composition characterization and quantification at the nanoscale level of fibers using Confocal Raman microscopy. The biodegradable/biocompatible nanofibers, Poly (glycerol-sebacate)/Poly (lactic-co-glycolic) (PGS/PLGA), were characterized as a part of a fiber scaffold to quickly and efficiently analyze the quality of the substrate used for tissue engineering.


This is the Publisher’s PDF of the following article made available by Optica Publishing Group: Lauren Sfakis, Anna Sharikova, David Tuschel, Felipe Xavier Costa, Melinda Larsen, Alexander Khmaladze, and James Castracane, "Core/shell nanofiber characterization by Raman scanning microscopy," Biomed. Opt. Express 8, 1025-1035 (2017)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.



Terms of Use

This work is made available under the Scholars Archive Terms of Use.