Date of Award

1-1-2012

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Biological Sciences

Content Description

1 online resource (vi, 39 pages) : PDF file, illustrations (some color)

Dissertation/Thesis Chair

Ben G Szaro

Committee Members

Gregory Lnenicka, Melinda Larsen

Keywords

Central Nervous System, Optic nerve, Regeneration, Retinal ganglion cells, Suppressor Of Cytokine Signaling, Xenopus laevis, Nervous system

Subject Categories

Biology | Neuroscience and Neurobiology

Abstract

The optic nerve and other central nervous system (CNS) axons tend to lose their capacity to regenerate following an injury in adult amniotes, but these axons are able to regenerate throughout life in anamniotes. The long-term goal of my study is to identify molecular mechanisms responsible for the retention of this regenerative capacity. Specifically, I will examine the role of the gene Suppressor of Cytokine Signaling 2 (SOCS2) in the successful regeneration of retinal ganglion cell (RGC) axons of the South African claw-toed frog, Xenopus laevis, after injury.

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