Date of Award
Bachelor of Arts
Starlette Douglass, B.A.
Ewan McNay, Ph.D.
Chronic high-fat feeding is associated with neuroinflammation, cognitive impairment, and anxiety-linked behaviors in rats. Metformin, a popular treatment for type II diabetes, has been shown to attenuate metabolic dysregulation and weight gain associated with an obesogenic diet. We demonstrated that HFD caused elevated fasting blood glucose, glucose intolerance, and increased body weight without cognitive impairment or anxiety as measured by novel object recognition and open field testing. Further, we demonstrated that metformin did not produce cognitive impairment, which was a concern associated with its chronic use. Further work will elucidate the impact of chronic HFD and metformin treatment on molecular markers of neuroinflammation and neural insulin resistance.
Levine, Caleb, "The effects of metformin on high-fat diet-induced neuroinflammation and cognitive impairment" (2020). Psychology. 44.