Date of Award

Spring 5-2020

Document Type

Honors Thesis

Degree Name

Bachelor of Arts



Advisor/Committee Chair

Starlette Douglass, B.A.

Committee Member

Ewan McNay, Ph.D.


Chronic high-fat feeding is associated with neuroinflammation, cognitive impairment, and anxiety-linked behaviors in rats. Metformin, a popular treatment for type II diabetes, has been shown to attenuate metabolic dysregulation and weight gain associated with an obesogenic diet. We demonstrated that HFD caused elevated fasting blood glucose, glucose intolerance, and increased body weight without cognitive impairment or anxiety as measured by novel object recognition and open field testing. Further, we demonstrated that metformin did not produce cognitive impairment, which was a concern associated with its chronic use. Further work will elucidate the impact of chronic HFD and metformin treatment on molecular markers of neuroinflammation and neural insulin resistance.