Date of Award

5-2011

Document Type

Honors Thesis

Degree Name

Bachelor of Science

Department

Biological Science

First Advisor

Hua Shi

Abstract

The protein B52 is an essential component of the spliceosome in Drosophila M. and is responsible for processing precursor-mRNA. B52 belongs to a family of proteins named SR proteins which are critical in initiation and commitment of RNA splicing. Analogous to human SRp55, B52 has been shown to be responsible for alternative and constitutive splicing during a multitude of cellular and developmental events. RNA aptamers selected during an in vitro selection and amplification process (SELEX) for B52 were found to have a co-variation in the stem of these aptamers. Using biochemical and structural techniques, I will explore the RNA-protein interaction and discuss possible uses for future cancer treatments.

Included in

Biology Commons

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