Date of Award

1-1-2012

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Epidemiology and Biostatistics

Program

Epidemiology

Content Description

1 online resource (xv, 167 pages)

Dissertation/Thesis Chair

Edward F Fitzgerald

Committee Members

David O Carpenter, Michael S Bloom, Francis P Boscoe, Richard F Haase

Keywords

arsenic, DNA repair polymorphism, non-melanoma skin cancer, occupational exposure, ultraviolet radiation, Skin, Basal cell carcinoma, Arsenic, Ultraviolet radiation

Subject Categories

Environmental Health | Epidemiology | Occupational Health and Industrial Hygiene

Abstract

Non-melanoma skin cancers (NMSC) comprise more than one third of all cancers, and are increasing worldwide. The most common NMSC are Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC). Studies on humans and animals suggest that sunlight and arsenic play important roles in the pathogenesis of these skin malignancies. However, the number of epidemiological studies focusing on NMSC in workers exposed to ultraviolet (UV) radiation or airborne arsenic is limited, and the findings are contradictory.

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