Date of Award
5-1-2022
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biomedical Sciences
Content Description
1 online resource (xiv, 165 pages) : illustrations (some color)
Dissertation/Thesis Chair
Alexander t Ciota
Committee Members
Kirsten St. George, Janice Pata, Paul Masters, Cara Pager, Laura Kramer
Keywords
fidelity, flavivirus, host switching, quasispecies, replicase, west nile virus, Flaviviruses, West Nile virus, Host-virus relationships, Microbial mutation
Subject Categories
Biochemistry | Microbiology | Virology
Abstract
Flaviviruses include several emerging and re-emerging arboviruses that cause millions of infections each year. Although relatively well-studied, much remains unknown regarding the mechanisms and means by which these viruses adapt to different hosts and rapidly alternate between hosts. Different aspects of flaviviral biology impact host switching, viral fitness, and the generation of viral diversity during genome replication by the NS3 and NS5 proteins. Together these factors may impact host plasticity.
Recommended Citation
Caldwell, Haley, "Characterization of the role of the replicase and quasispecies diversity in flaviviral evolution and host adaptation" (2022). Legacy Theses & Dissertations (2009 - 2024). 2871.
https://scholarsarchive.library.albany.edu/legacy-etd/2871