Date of Award
1-1-2010
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (ix, 136 pages) : illustrations (some color)
Dissertation/Thesis Chair
John T Welch
Committee Members
Richard Cunningham, Alexander Shekhtman, Carla Theimer, Hua Shi
Keywords
Antimycobacterial agents, Fatty acid synthesis inhibition, Mechanism of action, Pyrazinamide, Tuberculosis, Mycobacterium tuberculosis, Tuberculosis vaccines, Fatty acids, Isoniazid
Subject Categories
Biochemistry | Molecular Biology
Abstract
One third of the world's population is infected with M. tuberculosis, the causative agent of tuberculosis (TB) that claims the life of approximately 2 million people every year. The rapid spread of multidrug-resistance tuberculosis as well the emergence of extensively drug resistance strains that are resistant to virtually any known antibiotic, has transformed this once curable disease into a major public health challenge. To regain control of this disease and the associated mortality and morbidity new antibiotics are urgently needed.
Recommended Citation
Sayahi, Halimah, "Saturation transfer difference NMR studies : pyrazinamide and pyrazinamide analogs coordinating with Mycobacterium tuberculosis fatty acid synthase I (FAS I)" (2010). Legacy Theses & Dissertations (2009 - 2024). 256.
https://scholarsarchive.library.albany.edu/legacy-etd/256