Date of Award

1-1-2020

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Biological Sciences

Content Description

1 online resource (vi, 46 pages) : illustrations (chiefly color)

Dissertation/Thesis Chair

Paolo Forni

Keywords

Luteinizing hormone releasing hormone, GABA, Genetic sex determination, Developmental neurobiology, Puberty, Mice as laboratory animals, Rats as laboratory animals

Abstract

Gonadotropin-releasing hormone (GnRH) neurons are key regulators of sexual development and reproduction of animals from ascidians to vertebrates. Gamma-amino butyric acid (GABA) has been implicated, in literature, as one of the major players in the regulating GnRH neuronal development and neuronal activity. GABA usually acts as an inhibitory neurotransmitter, however, in GnRH neurons it has been described as an excitatory stimulus in different animal models. In my master thesis I will present and discuss a series of scientific articles on this topic to summarize the current understanding of how GABA signaling affects GnRH neuronal development and physiological activity in reproduction.

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