Date of Award
1-1-2018
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biological Sciences
Content Description
1 online resource (xxi, 191 pages) : color illustrations.
Dissertation/Thesis Chair
Prashanth Rangan
Committee Members
Marlene Belfort, Melinda Larsen, Paolo Forni, Jeremy Nance
Keywords
Germline stem cells, piRNAs, Rho GTPases, Transposons, Wnt signaling, Drosophila melanogaster, Stem cells, Germ cells, Drosophila, Cell differentiation, Cellular signal transduction, Chromatin
Subject Categories
Cell Biology | Developmental Biology | Molecular Biology
Abstract
Stem cells have the unique capability of self-renewing into stem cells and differentiating into several terminal cell types. Loss of either of these processes can lead to aging, progression towards degenerative diseases and cancers. Insight into how self-renewal and differentiation are regulated will have tremendous therapeutic impact. Drosophila is an excellent model system for stem cell study due to the availability of various mutants, markers and RNAi technology. In order to study stem cell biology, we use female Drosophila gonads, whose stem cell population – the germline stem cells (GSCs) gives rise to gametes.
Recommended Citation
Upadhyay, Maitreyi, "Chromatin-signaling axis orchestrates the formation of germline stem cell differentiation niche in drosophila" (2018). Legacy Theses & Dissertations (2009 - 2024). 2181.
https://scholarsarchive.library.albany.edu/legacy-etd/2181