Date of Award
1-1-2018
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (iii, xxvii, 167 pages) : illustrations (some color)
Dissertation/Thesis Chair
Rabi A Musah
Committee Members
Sridar V Chittur, Alexander Shekhtman, Dikarev Evgeny
Keywords
Cysteine, Carboranes, Boron-neutron capture therapy, Boron compounds, Boron Neutron Capture Therapy
Subject Categories
Chemistry
Abstract
Carbon-containing boranes, also known as carboranes, have attracted immense interest since their discovery in the 1950’s. Characterization of carboranes revealed their highly symmetrical polyhedral structures, which make them chemically and thermally stable. Their unique chemical properties, hydrophobicity and aromaticity also make them ideal candidates for a variety of applications. Prominent among these are the applications in materials and medicinal chemistry. On the materials chemistry front, carboranes have been investigated as self-assembly building blocks, liquid crystals and gas storage and separation materials. In the medicinal chemistry field, carborane derivatives have been extensively investigated as potential drugs, with a lot of attention being directed towards their use as boron neutron capture therapy agents for malignant human brain tumors.
Recommended Citation
He, Tianyu, "Carborane functionalized cysteine : synthesis, structural characterization, and biological evaluation for boron neutron capture therapy" (2018). Legacy Theses & Dissertations (2009 - 2024). 2068.
https://scholarsarchive.library.albany.edu/legacy-etd/2068