Date of Award
1-1-2017
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Environmental Health Sciences
Content Description
1 online resource (ii, xiii, 118 pages) : illustrations (some color)
Dissertation/Thesis Chair
Xinxin Ding
Committee Members
David Spink, Qing-Yu Zhang, Laurence Kaminsky, Thomas Begley
Keywords
bioactivation, naphthalene, P450, respiratory tract, Cytochrome P-450, Naphthalene, Pulmonary toxicology, Cytochrome P-450 Enzyme System
Subject Categories
Environmental Health | Toxicology
Abstract
Naphthalene (NA) is an omnipresent air pollutant and respiratory toxicant and a possible human lung carcinogen. NA induces cytotoxicity in airways following bioactivation by CYP (P450) enzymes. The overall goal of this study was to examine the relative contributions of hepatic and pulmonary CYPs to bioactivation, disposition and NA-induced pneumotoxicity in vivo. Substantial differences in the expression and enzymatic activity of P450s occur in various organs in human populations, which could modify susceptibility to NA-induced airway damage. The central hypothesis for this study was that NA has the potential to cause lung toxicity in humans and that the metabolism of NA in both lung and liver influence the consequence of NA exposure on an individual basis. Three projects were undertaken to address this hypothesis.
Recommended Citation
Kovalchuk, Nataliia, "Organ-specific contribution of P450 enzymes to bioactivation and acute respiratory tract toxicity of naphthalene" (2017). Legacy Theses & Dissertations (2009 - 2024). 1869.
https://scholarsarchive.library.albany.edu/legacy-etd/1869