Date of Award

1-1-2016

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Epidemiology and Biostatistics

Program

Epidemiology

Content Description

1 online resource (vii, 135 pages) : illustrations (some color)

Dissertation/Thesis Chair

Akiko Hosler

Committee Members

Emily Leckman-Westin, Gregory DiRienzo

Keywords

A1C, Antidepressants, Diabetes, Glycosylated hemoglobin, Depression, Mental, Depressed persons, Diabetics, Depression in old age

Subject Categories

Epidemiology

Abstract

While depression is known to increase the risk of diabetes and worsen glycemic control, the effect of antidepressants on these outcomes is unclear. Within the past few years, a cross-sectional study performed in a large, nationally-representative sample of individuals without diagnosed diabetes concluded that there are no differences between antidepressant users and non-users with regard to a number of diabetes-related outcomes including A1C, a measure of average glucose levels over the past few months commonly used to detect and monitor diabetes. The current set of studies was conducted to determine whether replicating this research in a higher-risk population or using more refined exposure categories would lead to similar conclusions.

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