Alternative ABL1 Isoform Expression in Oncogenic Translocations: Implications for Cancer Progression
Date of Award
Spring 5-2026
Language
English
Document Type
Honors Thesis
Degree Name
Bachelor of Science
Department
Biology
Advisor/Committee Chair
Douglas S. Conklin
Abstract
Abstract (also on poster): Previous studies in our lab show that an alternate isoform of Bruton’s tyrosine kinase, BTK-C, is required for the survival of several epithelial-derived cancer cells. BTK-C is transcribed from an alternative promoter and includes a 34-amino-acid N- terminal extension with a palmitoylation sequence that alters its subcellular localization. Nine other human kinases have similar alternative N-termini (ANT), often producing palmitoylated or non-palmitoylated isoforms from different transcriptional start sites. Among these, ABL1 is a known oncogenic kinase and key drug target. Translocation mutations at the 5′ end of ABL1 are a major cause of adult leukemias. This study will examine how these translocations affect ABL1 isoform expression in relation to cancer incidence, progression, and outcomes.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Teague, Jessica, "Alternative ABL1 Isoform Expression in Oncogenic Translocations: Implications for Cancer Progression" (2026). Biological Sciences. 112.
https://scholarsarchive.library.albany.edu/honorscollege_biology/112