Date of Award

5-1-2024

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Biological Sciences

Dissertation/Thesis Chair

Bijan BD Dey

Committee Members

Bijan BD Dey, Andy AB Berglund, Melinda ML Larsen

Subject Categories

Developmental Biology

Abstract

Skeletal muscle is essential in orchestrating voluntary movement and contributes to approximately half of the body's overall mass. Dysregulation in proper skeletal muscle development can lead to muscle degenerative disorders, such as severe Duchenne Muscular Dystrophy (DMD). Understanding the process of muscle development has been the central focus of numerous biological studies, focusing on myogenic transcription factors and signaling molecules like Pax3, Pax7, Myf5, MyoD, WNT, TGF-β, and BMP, IGF1, AKT/mTOR pathway. Also, studies have suggested that m6A (N6-methyladenosine) plays a crucial role in various biological processes, including skeletal muscle regeneration and development. m6A modification is the prevalent form of RNA methylation in eukaryotes, playing a pivotal role in the post-transcriptional control of gene expression. The goal of my library thesis is to review the significant role of m6A RNA methylation in processes encompassing skeletal muscle regeneration.

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