Date of Award
5-1-2024
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biological Sciences
Dissertation/Thesis Chair
Cara T Pager
Subject Categories
Biology
Abstract
Flavivirus infections pose significant global health risks, often leading to serious neurological and congenital complications such as microcephaly. These viruses induce complex cellular stress responses pathways encompassing the Unfolded Protein Response (UPR), Integrated Stress Response (ISR), autophagy, apoptosis, and the antiviral immune response, which dictate cell fate by either promoting survival to combat virus-induced damage or initiating cell death under prolonged stress. Despite the antagonizing functions, flaviviruses employ various subversion strategies, facilitated by viral proteins, to ensure successful infections even in the presence of activated cellular responses. Recent studies highlight dynamic interactions among stress response pathways during infection, emphasizing the need for further exploration.
Recommended Citation
Badu, Pheonah, "Interplay Between Cellular Stress Mechanisms And Immune Responses In Restricting Zika Virus Infection" (2024). Legacy Theses & Dissertations (2009 - 2024). 3286.
https://scholarsarchive.library.albany.edu/legacy-etd/3286