Date of Award
8-1-2023
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Dissertation/Thesis Chair
Jia Sheng
Committee Members
Alexander Shekhtman, Alan A Chen, Ting Wang, Ken Halvorsen
Subject Categories
Chemistry
Abstract
Developments in chemical synthesis of nucleic acid sequences and modifications have aided in the study of biomolecular interactions and the roles of modified nucleic acids in biology, medicine, and nanotechnology. This work describes some of the aspects of such developments, from synthesis of chemically modified RNA and DNA aptamers that can bind antibiotics and metal ions to the use of nucleic acids with novel backbone linkages in the construction of nanostructures. Analysis of such nucleic acid structures inform us on the basic structure of these molecules and the resulting functions that are applicable in fields such as biosensing, drug screening and drug delivery.
Recommended Citation
Mathivanan, Johnsi, "Exploiting Natural Rna 2′-5′-Linkage In Nucleic Acid Aptamers And Dna Nanostructures" (2023). Legacy Theses & Dissertations (2009 - 2024). 3187.
https://scholarsarchive.library.albany.edu/legacy-etd/3187