Date of Award

8-1-2023

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Chemistry

Dissertation/Thesis Chair

Jia Sheng

Committee Members

Alexander Shekhtman, Alan A Chen, Ting Wang, Ken Halvorsen

Subject Categories

Chemistry

Abstract

Developments in chemical synthesis of nucleic acid sequences and modifications have aided in the study of biomolecular interactions and the roles of modified nucleic acids in biology, medicine, and nanotechnology. This work describes some of the aspects of such developments, from synthesis of chemically modified RNA and DNA aptamers that can bind antibiotics and metal ions to the use of nucleic acids with novel backbone linkages in the construction of nanostructures. Analysis of such nucleic acid structures inform us on the basic structure of these molecules and the resulting functions that are applicable in fields such as biosensing, drug screening and drug delivery.

Included in

Chemistry Commons

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