Date of Award

12-1-2023

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Epidemiology and Biostatistics

Dissertation/Thesis Chair

Marilyn L. Browne

Committee Members

Melissa Tracy, Paul A Romitti

Keywords

alcohol, birth defects, craniosynostosis, gastroschisis, latent class analysis, omphalocele

Subject Categories

Epidemiology

Abstract

Maternal alcohol consumption during pregnancy is known to be associated with poor pregnancy outcomes, including fetal alcohol spectrum disorders. However, evidence for associations between alcohol consumption during pregnancy and some major structural birth defects among offspring is conflicting or inconclusive. This dissertation used data from the National Birth Defects Prevention Study (NBDPS), a multi-site, population-based case-control study, to examine associations between maternal alcohol consumption and risk of three major musculoskeletal birth defects: gastroschisis, omphalocele, and craniosynostosis. Our analyses built upon previous analyses of these associations using NBDPS data, including larger sample sizes and more robust analytic methods to explore issues related to alcohol consumption measurement, such as bias due to misclassification and the effect of using latent classes to define patterns of risky alcohol consumption.

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