Determining essential regulatory factors in Extravillous-Trophoblast differentiation and splice variants associated with the development of preeclampsia

Author

Brandt Hugh Beck, University at Albany, State University of New YorkFollow

Date of Award

Spring 2025

Language

English

Embargo Period

5-14-2025

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Biomedical Sciences

Program

Biomedical Sciences

First Advisor

Bum-Kyu Lee

Second Advisor

Douglas Conklin

Third Advisor

JoEllen Welsh

Committee Members

Bum-Kyu Lee, Douglas Conklin, JoEllen Welsh

Keywords

Placenta, Preeclampsia, Extrvillous-Trophoblast

Subject Categories

Biomedical Informatics | Disease Modeling | Medical Genetics | Tissues

Abstract

Preeclampsia is a common condition affecting mothers across the world. Rates for preeclampsia have been rising in the past years due to factors such as obesity and diabetes. Since this condition has been more prevalent, a better understanding of the factors surrounding the preeclamptic state are needed. Core cell types and biological functions of placenta development are known but the cause behind the preeclamptic environment is not well understood. This research aims to investigate the potential causes behind preeclampsia by first reviewing Extravillous-Trophoblast differentiation factors in the context of differential gene expression and alternative splicing then evaluate towards preeclamptic tissue. Extravillous-Trophoblasts are the architects behind spiral artery remodeling and are thought to be the cause of preeclampsia due to shallow spiral artery remodeling. With this information in hand preeclamptic data will be brought in to view differential gene expression and alternative splicing. The goal of this inspection is to find key differences between healthy Extravillous-Trophoblast phenotype and the preeclamptic phenotype. Finding potential genes pushing the preeclamptic state could lead to therapeutics to alleviate this condition.

License

This work is licensed under the University at Albany Standard Author Agreement.

Recommended Citation

Beck, Brandt Hugh, "Determining essential regulatory factors in Extravillous-Trophoblast differentiation and splice variants associated with the development of preeclampsia" (2025). Electronic Theses & Dissertations (2024 - present). 236.
https://scholarsarchive.library.albany.edu/etd/236